home
***
CD-ROM
|
disk
|
FTP
|
other
***
search
/
Shareware Overload Trio 2
/
Shareware Overload Trio Volume 2 (Chestnut CD-ROM).ISO
/
dir26
/
med9410p.zip
/
M94A3180.TXT
< prev
next >
Wrap
Text File
|
1994-10-25
|
2KB
|
38 lines
Document 3180
DOCN M94A3180
TI Evidence for HTLV-1 infection in Uganda.
DT 9412
AU Biryahwaho B; Downing RG; de The G; UVRI, Entebbe & Pasteur Institute,
Paris.
SO Int Conf AIDS. 1994 Aug 7-12;10(1):135 (abstract no. PA0159). Unique
Identifier : AIDSLINE ICA10/94369395
AB OBJECTIVE: To determine the seroprevalence of HTLV-1 in Uganda. METHODS:
Specimens for national HIV sentinel surveillance were collected from 5
antenatal clinics in 1992 as follows: Kampala, Kasese, Kisoro, Moroto
and Moyo. 425 specimens were selected at random and tested for
antibodies to HIV-1 by Recombigen HIV-1 EIA (Cambridge Biotech, USA) and
Wellcozyme HIV Recombinant (Murex, UK) with WB (Cambridge Biotech, USA)
where necessary. Specimens were also assayed on Retro Tek HIV-1/HTLV-1
Combination EIA (Cellular Products, USA). HTLV-1 particle agglutination
(PA) (Fujirebio, Japan), HTLV-1 EIA and HTLV-1 immunoblot (Diagnostic
Biotechnology, Singapore). RESULTS: 1) 92/425 sera were negative for
antibodies to HIV-1 but reactive on the HIV-1/HTLV-1 EIA. 2)
HTLV-1-specific reactivities clustered in Moroto, an area of low HIV-1
endemicity, populated by Nilo-Hamitic people. 3) 87/92 sera were assayed
by PA and HTLV-1 EIA; 17/87 were reactive by PA and 16/87 by HTLV-1 EIA.
4) only 9/87 sera were reactive by both PA and HTLV-1 EIA. 5) these 9
sera together with a further 10 sera with strong reactivities on HTLV-1
EIA were blotted; 18/19 were indeterminate on blotting and 1/19 was
negative. CONCLUSIONS: We found no evidence for HTLV-1 in this sample of
the Ugandan population. The clustering of HTLV-1 indeterminate serology
in Moroto justifies further investigations for novel human retroviruses.
DE Cluster Analysis Female Human HIV Antibodies/BLOOD HIV
Seroprevalence HIV-1 HTLV-I Infections/*EPIDEMIOLOGY Immunoblotting
Immunoenzyme Techniques Pregnancy Pregnancy Complications,
Infectious/*EPIDEMIOLOGY Prenatal Care Prevalence Uganda/EPIDEMIOLOGY
MEETING ABSTRACT
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).